Infecção por Papilomavírus Humano entre gestantes atendidas na atenção primária de saúde: um estudo transversal
Resumo
Objetivo: verificar a prevalência de Papilomavírus Humano em gestantes e a concordância da detecção entre amostras de urina e cérvico-vaginais. Métodos: foram colhidas amostras de 110 mulheres no segundo trimestre de gestação no município de Coari, Amazonas. A detecção do vírus foi feita através de Reação em Cadeia da Polimerase, utilizando-se o conjunto de iniciadores PGMY09/11. Resultados: 24,6% das gestantes estavam infectadas, estando o vírus presente em 11,8% das amostras de urina e em 23,6% das amostras cérvico-vaginais. Houve concordância de 86,4% e índice de concordância moderado entre as amostras biológicas (kappa = 0,543). Foi encontrada associação estatisticamente significativa entre a infecção pelo Papilomavírus Humano e as variáveis: idade das gestantes (p= 0,014), primigestação (p= 0,027) e nuliparidade (p= 0,046). Conclusões: a amostra cérvico-vaginal mostrou-se mais adequada para detecção do vírus e a alta prevalência encontrada reforça a necessidade de acompanhar com mais atenção esta infecção na fase gestacional.Downloads
Referências
Condrat CE, Filip L, Gherghe M, Cretoiu D, Suciu N. Maternal HPV infection: Effects on pregnancy outcome. Viruses. 2021;13(12):1–21. DOI: https://doi.org/10.3390/v13122455
Chilaka VN, Navti OB, Al Beloushi M, Ahmed B, Konje JC. Human papillomavirus (HPV) in pregnancy – An update. Eur J Obstet Gynecol Reprod Biol. 2021;264:340–8. DOI: https://doi.org/10.1016/j.ejogrb.2021.07.053
Benedict JJ, Derkay CS. Recurrent respiratory papillomatosis: A 2020 perspective. Laryngoscope Investig Otolaryngol. 2021;6(2):340–5. DOI: https://doi.org/10.1002%2Flio2.545
Pandey D, Solleti V, Jain G, Das A, Shama Prasada K, Acharya S, et al. Human Papillomavirus (HPV) infection in early pregnancy: prevalence and implications. Infect Dis Obstet Gynecol. 2019;2019. DOI: https://doi.org/10.1155/2019/4376902
Mix JM, Gopalani SV, Simko S, Saraiya M. Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001–2017. Prev Med. 2022;164:107302. DOI: https://doi.org/10.1016/j.ypmed.2022.107302
Clarke MA, Deshmukh AA, Suk R, Roberts J, Gilson R, Jay N, et al. A systematic review and meta‐analysis of cytology and HPV‐related biomarkers for anal cancer screening among different risk groups. Int J Cancer. 2022;151(11):1889–901. DOI: https://doi.org/10.1002/ijc.34199
González-Guevara MB, Linares-Vieyra C, Castro-García ME, Muñiz-Lino MA, Abaroa-Chauvet C, Bello-Torrejón F. Carcinoma escamocelular bucal. Caso clínico y revisión de la literatura. Rev Med Inst Mex Seguro Soc. 2021;60(1). Disponible en: https://docs.bvsalud.org/biblioref/2022/03/1361682/4215-29326-1-pb.pdf
Curty G, De Carvalho PS, Soares MA. The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer. Int J Mol Sci. 2019;21(1):222. DOI: https://doi.org/10.3390/ijms21010222
Ardekani A, Sepidarkish M, Mollalo A, Afradiasbagharani P, Rouholamin S, Rezaeinejad M, et al. Worldwide prevalence of human papillomavirus among pregnant women: a systematic review and meta-analysis. Rev Med Virol. 2023;33(1):1–13. DOI: https://doi.org/10.1002/rmv.2374
Freitas LB, Pereira CC, Checon R, Leite JPG, Nascimento JP, Spano LC. Adeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women. Eur J Obstet Gynecol Reprod Biol. 2009;145(1):41–4. DOI: https://doi.org/10.1016/j.ejogrb.2009.03.024
Salcedo MMBP, Damin APS, Agnes G, Pessini SA, Beitune PE, Alexandre COP, et al. Prevalence of human papillomavirus infection in pregnant versus non-pregnant women in Brazil. Arch Gynecol Obstet. 2015;292(6):1273–8. DOI: https://doi.org/10.1007/s00404-015-3752-8
Pereira SMM, Etlinger D, Aguiar LS, Peres SV, Filho AL. Simultaneous Chlamydia trachomatis and HPV Infection in Pregnant Women. Diagn Cytopathol. 2010;38(6):397–401. DOI: https://doi.org/10.1002/dc.21219
Souza HD, Waissman AL, Diório GRM, Peres SV, Francisco RPV, Galletta MAK. Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes. Clinics (Sao Paulo). 2022;77:100127. DOI: https://doi.org/10.1016/j.clinsp.2022.100127
Meyrelles ARI, Siqueira JD, Hofer CB, Costa TP, Azevedo AP, Guimarães BV, et al. HIV/HPV co-infection during pregnancy in southeastern Brazil: Prevalence, HPV types, cytological abnormalities and risk factors. Gynecol Oncol. 2013;128(1):107–12. DOI: https://doi.org/10.1016/j.ygyno.2012.10.003
Brandao VCRAB, Lacerda HR, Lucena-Silva N, Ximenes RA de A. Frequency and types of human papillomavirus among pregnant and non-pregnant women with human immunodeficiency virus infection in Recife determined by genotyping. Mem Inst Oswaldo Cruz. 2009;104(5):755–63. DOI: https://doi.org/10.1590/s0074-02762009000500016
Ministério da Saúde (BR). Departamento de Informática do Sistema Único de Saúde (DATASUS). Sistema de Informação de Nascidos Vivos (SINASC). Nascimentos em Coari - Amazonas. 2013. [acesso em 2015 maio 10]. Disponível em: http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sinasc/cnv/nvam.def
Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlée F, Hildesheim A, et al. Improved Amplification of Genital Human Papillomaviruses. J Clin Microbiol. 2000;38(1):357–61. DOI: https://doi.org/10.1128/jcm.38.1.357-361.2000
Bernard HU, Chan SY, Manos MM, Ong CK, Villa LL. Identification and assessment of known and novel human papillomaviruses by polymerase chain reaction amplification, restriction fragment length polymorphisms, nucleotide sequence, and phylogenetic algorithms. The Journal of Infectious Diseases.1994;170(5):1077-85. DOI: https://doi.org/10.1093/infdis/170.5.1077
Kudela E, Liskova A, Samec M, Koklesova L, Holubekova V, Rokos T, et al. The interplay between the vaginal microbiome and innate immunity in the focus of predictive, preventive, and personalized medical approach to combat HPV-induced cervical cancer. EPMA J. 2021;12(2):199–220. DOI: https://doi.org/10.1007/s13167-021-00244-3
Condrat CE, Cretoiu D, Radoi VE, Mihele DM, Tovaru M, Bordea CI, et al. Unraveling Immunological Dynamics: HPV Infection in Women—Insights from Pregnancy. Viruses. 2023;15(10):2011. DOI: https://doi.org/10.3390/v15102011
Smith EM, Johnson SR, Jiang D, Zaleski S, Lynch F, Brundage S, et al. The association between pregnancy and human papilloma virus prevalence. Cancer Detect Prev 1991;15(5):397–402.
Luo D, Peng M, Wei X, Pan D, Xue H, Xu Y, et al. Prevalence of human papillomavirus and genotype distribution in pregnant and non-pregnant women in china. Risk Manag Healthc Policy. 2021;14:3147–57. DOI: https://doi.org/10.2147/rmhp.s288838
Dousti R, Allahqoli L, Ayar Kocaturk A, Hakimi S. Can human papillomavirus vaccination during pregnancy result in miscarriage and stillbirth? A meta-analysis and systematic review. Eur J Midwifery. 2023;29(7):1–6. DOI: https://doi.org/10.18332/ejm/161793
Yuill S, Velentzis LS, Smith M, Egger S, Wrede CD, Bateson D, et al. The impact of HPV vaccination beyond cancer prevention: effect on pregnancy outcomes. Hum Vaccin Immunother. 2021;17(10):3562–76. DOI: https://doi.org/10.1080%2F21645515.2021.1936860
Batista SJS, Gomes AMP, Oliveira TKLD, Lobato TCL, Dantas JDS, Oliveira FGD, et al. Home Self-collection to test for Human Papillomavirus and Chlamydia trachomatis infection in riverside women in Amazonas. Research, Society and Development. 2023;12(3):e16412340171. DOI: https://doi.org/10.33448/rsd-v12i3.40171
Chatzistamatiou K, Sotiriadis A, Agorastos T. Effect of mode of delivery on vertical human papillomavirus transmission - A meta-analysis. J Obstet Gynaecol. 2016;36(1):10–4. DOI: https://doi.org/10.3109/01443615.2015.1030606
Petca A, Borislavschi A, Zvanca M, Petca RC, Sandru F, Dumitrascu M. Non-sexual HPV transmission and role of vaccination for a better future (Review). Exp Ther Med. 2020;20(6):1–1. DOI: https://doi.org/10.3892/etm.2020.9316
Bruno MT, Caruso S, Bica F, Arcidiacono G, Boemi S. Evidence for HPV DNA in the placenta of women who resorted to elective abortion. BMC Pregnancy Childbirth. 2021;21(1):485. DOI: https://doi.org/10.1186/s12884-021-03937-9
Wang A, Liu C, Wang Y, Yin A, Wu J, Zhang C, et al. Pregnancy Outcomes After Human Papillomavirus Vaccination in Periconceptional Period or During Pregnancy: A Systematic Review and Meta-analysis. Hum Vaccin Immunother. 2020;16(3):581–9. DOI: https://doi.org/10.1080/21645515.2019.1662363
Arora M, Lakshmi R. Vaccines - safety in pregnancy. Best Pract Res Clin Obstet Gynaecol. 2021;76:23–40. DOI: https://doi.org/10.1016/j.bpobgyn.2021.02.002
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